If your database, or any attached back-end databases, are getting close to the 2 GB maximum size limit, this could cause any number of random problems. Remember, Access is constantly working with hidden index and system tables. If it can't create or modify any of these, for any reasons, you might get weird errors. Try to keep your database files under 1.5 GB if possible. If not, split them. If you have a single table over 1 GB, you should optimize it, dump old data, or upgrade to SQL Server.
Oh, and this goes without saying: Check Remaining Hard Drive Space. Check to make sure you have plenty of free space available on your hard drive. You should have at least twice the space available as your database file size. So if you have a 1.5 GB database, you should have at LEAST 3 GB of free space available. If not, free up some space or upgrade your drive.
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