Not quite a simple yes.  But yes, you can append records to pretty much any table.  

If there is a dependency on other records in a different table so as not to create orphaned records it becomes more complex.

A little bit of explanation what you are attempting or wanting to accomplish would be useful here.

I want to import an employee list from excel (150 employees). I have the relationships set up with other helper tables and contacts table just for testing. I can delete all the relationships and contact information, would that work?
Thanks.

Ravi -

I suggest that you take a look at a couple of videos to prepare.
Multi-Table Update
Update Queries
Import Data


First and foremost make a back up of your db.  Then try out your import on a copy of your data to make sure it is doing what you want it to. You should be able to maintain your relationships.  Just a little bit more involved.
The videos above should help you out.

Thank you Scott.
Kind regards.